Determination of the Bone Lacunar Canalicular Permeability by Harmonic Loading
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چکیده
INTRODUCTION: Both theoretical and experimental evidence indicate that physiological deformations of bone tissue are not sufficient to stimulate osteocytes, the sensory cells in bone [1,2]. Indeed, it is believed that the interstitial fluid flow in the lacunar-canalicular porosity (PLC) plays an important role in amplifying bone tissue strains to the level osteocytes can sense[1,2], which is at the origin of the mechanotransduction mechanism in bone. One of the most influential parameters of the interstitial fluid flow is the PLC permeability that has been measured using different approaches and reported to vary within eight order of magnitude from 10 to 10 m [3-6]. Moreover, the frequency-dependent magnitude of the PLC permeability has not yet been evaluated. The objective of this research is to determine accurately the permeability of the PLC at different frequencies using an analytical poroelastic model and a micromechanical loading experiment.
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